Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG) n coding for polyglutamine and (GGC) n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with
Association of a CYP17 Polymorphism with Overall Survival in Caucasian Patients with Androgen-Independent Prostate Cancer
β Scribed by Akinobu Hamada; Romano Danesi; Douglas K. Price; Tristan Sissung; Cindy Chau; David Venzon; Alex Sparreboom; William L. Dahut; William D. Figg
- Book ID
- 116947763
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 120 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0090-4295
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CYP17 encodes the enzyme cytochrome P-450c17β£, which mediates both 17β£-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog
## Abstract Androgenβdeprivation therapy (ADT) is the most common therapy for advanced prostate cancer, but the prognosis significantly differs among individuals. In this study, we evaluated recently identified 19 prostate cancer susceptibility variants as prognostic predictors for the survival aft