A polymorphic system related to but genetically independent of the chicken major histocompatibility complex

✍ Scribed by W. Elwood Briles; Ronald M. Goto; Charles Auffray; Marcia M. Miller

• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 749 KB
• Volume: 37
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00222464

✦ Synopsis

Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction fragments for Mhc class I and/or class II genes has been found among DNA samples collected from birds homozygous for a single serologically defined B haplotype. Such findings have been interpreted as evidence for variability within the Mhc haplotypes of chickens not detected previously with serological methods. In this study of a fully pedigreed family over three generations, the heterogeneity observed in restriction fragment patterns was found to be the result of the presence of a second, independently segregating polymorphic Mhc-like locus, designated Rfp-Y. Three alleles (haplotypes) are identified in this new system.