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A genetic polymorphism of the complement component factor B in chickens not linked to the Major Histocompatibility Complex (MHC)

โœ Scribed by Claus Koch

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
369 KB
Volume
23
Category
Article
ISSN
0093-7711

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โœฆ Synopsis

The complement component factor B in chickens exhibits a genetic polymorphism with three common phenotypes, F, F/S, and S. These phenotypes segregate in flocks of chickens homozygous for the MHC (B complex) of the chicken. Furthermore, a genetic analysis has shown that the described factor B polymorphism is not linked to the B complex. It is not known whether the molecular basis for this polymorphism is due to the existence of allelic forms of the structural gene or to some posttranslational modifications, but the finding is discussed in view of the close linkage of factor B polymorphism with the MHC of all mammalian species investigated so far.

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โœ W. Elwood Briles; Ronald M. Goto; Charles Auffray; Marcia M. Miller ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 749 KB

Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction