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A polymeric form of haptoglobin in the gamma-irradiated Spanish goat

✍ Scribed by James C. Travis; Sidney O. Brown; Bob G. Sanders

Book ID
104785158
Publisher
Springer
Year
1970
Tongue
English
Weight
618 KB
Volume
4
Category
Article
ISSN
0006-2928

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✦ Synopsis

The haptoglobins (Hp) of control and gamma-irradiated Spanish goats were examined. Polyacrylamide gel electrophoresis and Sephadex G-200 chromatography of sera demonstrated that unirradiated controls were ahaptoglobinemic, while irradiated animals developed high Hp levels. An electrophoretic comparison with human Hp phenotypes revealed that goat Hp more closely resembled human Hp 2 than the other two human phenotypes. No eIectrophoretic band comparable to human Hp 1 appeared in the goat electrophoretic pattern. When goat Hp was tested by immunodiffusion with antiserum to human Hp, no reactivity was observed," however, goat Hp and the three human Hps bound goat, human, and chicken hemoglobins with equal specfcity, indicating some degree of structural homology between human and goat Hp. Suggestions as to the effects of irradiation to augment Hp synthesis and speculations about the chain composition and molecular weights of goat Hp are presented.

πŸ“œ SIMILAR VOLUMES

Haptoglobin evolution: Polymeric forms o
Haptoglobin evolution: Polymeric forms of HP in the Bovidae and Cervidae families
✍ Travis, James C. ;Sanders, Bob G. πŸ“‚ Article πŸ“… 1972 πŸ› John Wiley and Sons 🌐 English βš– 591 KB

Vertical polyacrylamide gel electrophoresis and Sephadex G-200 chromatography have been used to characterize haptoglobins (Hp) of members of the Bovidae family, goats, sheep, cattle, and bison, and of the Cervidae family, mule deer and elk. In contrast to other mammals with the