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A Plasma Concentration of -Ketoglutarate Influences the Kinetic Interaction of Ligands with Organic Anion Transporter 1

✍ Scribed by Ingraham, L.; Li, M.; Renfro, J. L.; Parker, S.; Vapurcuyan, A.; Hanna, I.; Pelis, R. M.


Book ID
121842391
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
350 KB
Volume
86
Category
Article
ISSN
0026-895X

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Secretion of small molecules from the systemic blood circulation into urine is one of the physiologically essential functions of the kidney. The human organic anion transporter (hOAT1) is a key component in the renal tubular secretion of negatively charged molecules including a variety of important