𝔖 Bobbio Scriptorium
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A ‘plaidoyer’ in favour of the melanocyte test for economic in vivo studies on gene mutations in somatic cells of mice

✍ Scribed by D. Harnasch

Book ID
113250890
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
54 KB
Volume
130
Category
Article
ISSN
0165-1161

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The retinal pigment epithelium (RPE) consists of a single layer of hexagonal cells, numbering about 10(5) in the 3-day mouse. Examination of the fixed and cleared RPE of mice homozygous for the unstable allele of pink-eye (pun), which shows a relatively high frequency of reversion to wild type, has