In a double-blind trial, 22 patients treated with 5 mg b.i.d. of the selective serotonin-S2 antagonist ritanserin for 4 weeks were compared with 26 patients treated with placebo for generalized anxiety disorder (DSM 111: 300.02). Symptoms were assessed using the Hamilton Anxiety Rating Scale (HARS)
A placebo controlled trial of diazepam and oxprenolol for anxiety
β Scribed by G. D. Burrows; B. Davies; L. Fail; C. Poynton; H. Stevenson
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 235 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
Sixty-two patients with moderately severe anxiety symptoms were treated in a double bline 3-week trial with either oxprenolol, diazepam or placebo. The Hamilton Anxiety Scale and a Target symptom improvement score were the main measures of change used. All treatment groups significantly improved in the three weeks of the trial. However in the third week of treatment improvement was greater in the diazepam and oxprenolol groups. Observer preferences significantly favoured the diazepam group. The implications of the study were discussed.
π SIMILAR VOLUMES
The effects of doxepin and diazepam upon anxiety states were studied in a double-blind controlled trial which involved 50 anxious neurotics. The drugs were prescribed for three weeks and there were no drop-outs. The mean dose of doxepin was 113 rag/day and of diazepam 21 mg/day. Ratings of anxiety
## Abstract The purpose of this article is to clarify the decision points that are important to consider when evaluating the ethics of a placeboβcontrolled trial. The ethical requirements for research involving human subjects are reviewed, and the rationale for and potential problems with concomita
## Methods Myopathy occurs in association with human immunodeficiency virus type 1 (HIV-1) infection, 2,8,17,19 and AIDS Clinical Trials Group (ACTG) Protocol 016 was designed to explore the safety and efficacy of ZDV as toxicity of the antiretroviral agent zidovudine (ZDV, AZT). 3,6,9,15 Retrospe
Background: Dopamine agonists could theoretically normalize the suspected central dopamine hypersensitivity in Tourette's syndrome. Methods: There was a multicenter randomized, placebo-controlled, double-blind clinical trial of pramipexole given for 6 weeks in 63 children and adolescents with Touret