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A comparative trial of doxepin and diazepam in anxiety states

✍ Scribed by G. N. Bianchi; J. Phillips

Publisher: Springer
Year: 1972
Tongue: English
Weight: 508 KB
Volume: 25
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00422620

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of doxepin and diazepam upon anxiety states were studied in a double-blind controlled trial which involved 50 anxious neurotics.

The drugs were prescribed for three weeks and there were no drop-outs.

The mean dose of doxepin was 113 rag/day and of diazepam 21 mg/day. Ratings of anxiety, physical symptoms and depression were made on entry to the trial and after 7, 14 and 21 days.

The drugs proved to be of comparable efficacy in decreasing anxiety and somatic complaints but doxepin controlled depressive symptoms better. Patients taking diazepam suffered more often from drowsiness, muscular weakness and constipation.

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