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A physiologically based kinetic (PBK) model for safrole bioactivation and detoxification in rat and comparison to those for estragole and methyleugenol

โœ Scribed by E. Martati; M. Boersma; A. Spenkelink; D. Khadka; A. Punt; J. Vervoort; P. van Bladeren; I.M.C.M. Rietjens


Book ID
116924464
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
86 KB
Volume
205
Category
Article
ISSN
0378-4274

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## Abstract In chemical safety assessment, information on adverse effects after chronic exposure to low levels of hazardous compounds is essential for estimating human risks. Results from __in vitro__ studies are often not directly applicable to the __in vivo__ situation, and __in vivo__ animal stu