A PHOTOLABILE PROTECTING GROUP FOR THE PHENOLIC HYDROXYL FUNCTION OF TYROSINE
β Scribed by Amit, Boaz ;Hazum, Eli ;Fridkin, Mati ;Patchornik, Abraham
- Book ID
- 115097331
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 386 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0367-8377
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π SIMILAR VOLUMES
Versatile use of 4-nitrobenzyl group for protection of hydroxyl functions is described. It can be removed selectively in the presence of other benzyl-type protecting groups such as benzyl and 4-methoxybenzyl via reduction into 4-aminobenzyl group followed by electrochemical oxidation. Very clean o
P-Methoxyphenacyloxycarbonyl (Phenoc) is a new photolabile protective group for ami nes. Various phenacyl urethanes, i.e. Phenoc protected amines, have been prepared. An appli cation of the group in peptide synthesis is reported. Various protective groups for amines are known'.
During the course of various synthetic projects under study in these Laboratories we have had occasion to devise and apply a number of new methods for the protection of hydroxyl' , carbony and la&one' functions. 4 We now wish to report some recent results on the protection of aldehydes and ketones