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A phase III trial of subcutaneous administration of rhG-CSF in the myelodysplastic syndromes

✍ Scribed by Y. Yoshida


Book ID
113239971
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
184 KB
Volume
18
Category
Article
ISSN
0145-2126

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## Abstract ## BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.