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A phase I/II study of the 5-HT3 antagonist GR38032F in the anti-emetic prophylaxis of patients receiving high-dose cisplatin chemotherapy

✍ Scribed by D. B. Smith; E. S. Newlands; G. J. S. Rustin; R. H. J. Begent; S. M. Crawford; K. D. Bagshawe; L. Carruthers


Publisher
Springer
Year
1990
Tongue
English
Weight
379 KB
Volume
25
Category
Article
ISSN
0344-5704

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GR38032F, a 5HT3receptor antagonist, in
✍ Michel Marty; Jean P. Droz; Pierre Pouillart; Bernard Paule; Nils Brion; Jacques πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 330 KB

A total of 28 patients receiving cancer chemotherapy with cisplatin-containing regimens (70-120 mg/ m 2) participated in an evaluation of the efficacy and safety of GR38032F for the prevention of acute nausea and vomiting. GR38032F, a 5HT3 receptor antagonist, was given 30 min prior to cisplatin as

The feasibility of neoadjuvant high-dose
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## Abstract ## BACKGROUND The primary and secondary objectives of the current study were to improve the β‰₯ 90% tumor necrosis rate and assess the toxicity profile of the neoadjuvant high‐dose chemotherapy (HDC) regimen, respectively. ## METHODS Twenty‐two patients with AJCC Stage IIB high‐grade o