A phase II trial of tamoxifen, premarin, methotrexate and 5-fluorouracil in metastatic breast cancer
โ Scribed by Joseph C. Allegra; Thomas M. Woodcock; Stephen P. Richman; Kirby I. Bland; James L. Wittliff
- Publisher
- Springer US
- Year
- 1982
- Tongue
- English
- Weight
- 773 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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Forty-six eligible patients with metastatic breast cancer (MBC) were treated with a combination of methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) as first-line chemotherapy. Of 44 patients evaluable for response, 28 (64%) had an objective response, including seven (16%) who had a comp
## Background: High-dose chemotherapy with hematopoietic support produces high rates of response in metastatic breast cancer. to facilitate new high-dose regimens there is a need to identify active agents with toxicity limited to hematopoietic suppression. cisplatin/etoposide is a highly active reg