## Abstract ## BACKGROUND. Patients with metastatic osteosarcoma have a poor prognosis. The objectives of the study were to determine the antitumor activity and toxicity of topotecan (daily Γ5) in newly diagnosed patients with metastatic osteosarcoma followed by chemotherapy (ifosfamide, carboplat
A phase II trial of ifosfamide in previously untreated children and adolescents with unresectable rhabdomyosarcoma
β Scribed by Alberto S. Pappo; Erlinda Etcubanas; Victor M. Santana; Bhaskar N. Rao; Larry E. Kun; James Fontanesi; Paula K. Roberson; Laura C. Bowman; William M. Crist; David N. Shapiro
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 680 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## Background The cure rate for children/adolescents with localized rhabdomyosarcoma (RMS) has tripled over the past 25 years, but patients with metastatic disease at presentation have not benefited similarly, and urgently need new therapy. We evaluated a new drug pair, ifosfamideβ+βdo
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