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A phase II study of sequential methotrexate and 5-fluorouracil in colorectal carcinoma

✍ Scribed by M. J. Harding; S. B. Kaye; M. Soukop; J. C. Ferguson

Book ID
112970889
Publisher
Springer US
Year
1988
Tongue
English
Weight
245 KB
Volume
5
Category
Article
ISSN
1357-0560

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Twenty-nine patients with advanced colorectal cancer were treated with methotrexate (MTX) 200 mg/m2 followed 1 h later by fluorouracil (FU) (1000 mg/m2) and 24 h later by oral leucovorin 20 mg every 6 h for six doses. The cycle was repeated every 2 weeks. Among the 25 evaluable patients there were 2

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## Background and Objectives: The present study compared the effects of sequential methotrexate and fluorouracil followed by leucovorin rescue (MFL), as an adjuvant chemotherapy versus a combination of tegafur (UFT) and mitomycin C (MMC), on patient survival and recurrence after surgery for colore