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A phase II study of sequential combination chemotherapy with cyclophosphamide, prednisone, and 2-chlorodeoxyadenosine in previously untreated patients with chronic lymphocytic leukemia

โœ Scribed by Tefferi, A; Li, C-Y; Reeder, C B; Geyer, S M; Allmer, C; Levitt, R; Michalak, J C; Addo, F; Krook, J E; Witzig, T E

Book ID
110054937
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
113 KB
Volume
15
Category
Article
ISSN
0887-6924

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โœ Marco Montillo; Alessandra Tedeschi; Susan O'Brien; Francesco Di Raimondo; Susan ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 85 KB ๐Ÿ‘ 1 views

## Abstract ## BACKGROUND One of the mechanisms of action of cladribine is the inhibition of DNA repair of damage caused by radiation, alkylating agents, or other drugs. To determine its antitumor activity in combination with cyclophosphamide, we initiated a Phase II trial of the two agents in pat