A phase I study of imatinib mesylate in combination with chlorambucil in previously treated chronic lymphocytic leukemia patients
β Scribed by Jonathan Hebb; Sarit Assouline; Caroline Rousseau; Pierre DesJardins; Stephen Caplan; Merrill J. Egorin; Lilian Amrein; Raquel Aloyz; Lawrence Panasci
- Book ID
- 105993644
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 325 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND. The tolerability and efficacy of the combination of tipifarnib, an orally bioavailable nonpeptidomimetic farnesyl transferase inhibitor, and imatinib was investigated in patients with chronic myelogenous leukemia in chronic phase who had failed imatinib. ## METHODS. Tw
## Abstract ## BACKGROUND Imatinib mesylate induces high rates of hematologic and cytogenetic response in patients with chronic myelogenous leukemia (CML). During therapy with imatinib, up to 45% of patients with CML reportedly experience myelosuppression β₯ Grade 3, requiring interruption of thera