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A phase-II study of low-dose cyclophosphamide and recombinant human interleukin-2 in metastatic renal cell carcinoma and malignant melanoma

✍ Scribed by Albrecht Lindemann; Klaus Höffken; Reinhold E. Schmidt; Volker Diehl; Otto Kloke; Heinold Gamm; Jörg Hayungs; Wolfgang Oster; Markus Böhm; Jonathan E. Kolitz; Chris R. Franks; Friedhelm Herrmann; Roland H. Mertelsmann

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
937 KB
Volume
28
Category
Article
ISSN
0340-7004

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✍ A. Mittelman; M. Huberman; C. Puccio; B. Fallon; J. Tessitore; S. Savona; R. Eyr 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 662 KB

Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN