## Abstract ## BACKGROUND The objectives of the current study were to evaluate the safety and efficacy of gemcitabine plus docetaxel in patients with unresectable (Stage T4 or β₯ N1) metastatic or locally advanced transitional cell carcinoma (TCC) of the urothelial tract. ## METHODS A total of 27
A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma
β Scribed by David P. Ryan; Matthew H. Kulke; Charles S. Fuchs; Michael L. Grossbard; Steven R. Grossman; Jeffrey A. Morgan; Craig C. Earle; Ramesh Shivdasani; Haesook Kim; Robert J. Mayer; Jeffrey W. Clark
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 87 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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A Phase I study was initiated to determine the maximum tolerated dose of weekly gemcitabine combined with monthly, fixed-dose docetaxel. ## METHODS. Patients with metastatic solid tumors were treated with docetaxel, 60 mg/m 2 , on Day 1 every 28 days. Gemcitabine was administered on Days 1, 8, and
## Abstract ## BACKGROUND The similarity between the mechanism of action between docetaxel and estramustine generated the hypothesis of synergistic antimicrotubule effects and cytotoxicity when the two agents are combined. In addition, it has been demonstrated that estramustine binds Pβglycoprotei