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A phase II study of combined administration of dacarbazine and carboplatin with home therapy of recombinant interleukin-2 and interferon-α2a in patients with advanced malignant melanoma

✍ Scribed by Han G. Ron; Yair Mordish; Avi Eisenthal; Yehuda Skornick; Moshe J. Inbar; Samario Chaitchik


Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
584 KB
Volume
38
Category
Article
ISSN
0340-7004

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Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN