A phase I-II study of dacarbazine in combination with outpatient interleukin-2 in metastatic malignant melanoma
โ Scribed by Lawrence E. Flaherty; Bruce G. Redman; Guy G. Chabot; Silvana Martino; Steven M. Gualdoni; Lance K. Heilbrun; Manuel Valdivieso; Edward C. Bradley
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 699 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Nineteen patients with advanced malignant melanoma were treated with a combination of recombinant alfa-interferon (a-IFN) and vinblastine (VBL). The a-IFN was administered subcutaneously daily at an initial dose of 3 X lo6 IU escalating to a maximal dose of 9 X lo6 U daily for the first 10 weeks fol
## BACKGROUND. Few studies have examined the feasibility, safety, and efficacy of an outpatient biochemotherapy regimen of low dose, subcutaneously administered interleukin-2 (IL-2) for patients with metastatic (Stage IV) melanoma. ## METHODS. Nineteen patients were treated with intravenous cispl