A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma
β Scribed by Monica M. Mita; Eric K. Rowinsky; Leonardo Forero; S. Gail Eckhart; Elzbieta Izbicka; Geoffrey R. Weiss; Muralidhar Beeram; Alain C. Mita; Johann S. de Bono; Anthony W. Tolcher; Lisa A. Hammond; Paul Simmons; Kristin Berg; Chris Takimoto; Amita Patnaik
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 353 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
The National Cancer Institute of Canada Clinical Trials Group conducted a phase II study of spirogermanium given daily for 5 days every 3 weeks to previously untreated patients with malignant melanoma. In 21 evaluable patients one complete response was seen (response rate 5%). Disease progression oc
## Abstract ## BACKGROUND Temozolomide plus thalidomide is a promising oral combination regimen for the treatment of metastatic melanoma. The current Phase II study examined the efficacy and safety of this combination in chemotherapyβnaive patients with brain metastases. ## METHODS Patients with
by 40 mg to the MTD in groups of 3 patients. DDP (80 mg/m 2 ) was begun on Day ogy/Oncology, Hollings Cancer Center, Medical 2 and repeated weekly for a total of 3 weeks. During Week 4, the patients were University of South Carolina, Charleston, South not treated with DDP but instead evaluated for r