Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors
โ Scribed by Kimberly A. Varker; Jacqueline Campbell; Manisha H. Shah
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 287 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0344-5704
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## Background: Octreotide, a long-acting somatostatin analogue, has demonstrated clinical utility in patients with carcinoid syndrome and malignant islet cell tumors of the pancreas. prior studies have reported a greater than expected incidence of cholelithiasis in patients treated with octreotide
Background. The use of chemotherapy in patients with metastatic carcinoid tumors has been of limited value, and investigiition of new agents is necessary. Previous reports have suggested that dimethyltriazenoimidazole carboxamide (DTIC) may have antitumor activity. Methods. A Phase I1 trial to inve