## BACKGROUND. Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-ho
A phase II evaluation of thiotepa in pediatric central nervous system malignancies
โ Scribed by Richard L. Heideman; Roger J. Packer; Gregory H. Reaman; Jeffrey C. Allen; Beverly Lange; Marc E. Horowitz; Seth M. Steinberg; Andrea Gillespie; Edward H. Kovnar; Frank M. Balis; David G. Poplack
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 489 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
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