## BACKGROUND. This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin. ## METHODS. Pelvic radiation therapy consisted of 50.4 -54 gray (Gy) administered in 28 -30 fractions. Systemic treatment
A phase I study of thiotepa administered by short-term and protracted continuous intravenous infusion
β Scribed by Jacob J. Lokich; Merrill J. Egorin; Brian E. Cohen; Murray M. Bern; Thomas E. Zipoli; Cheri Moore
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 507 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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Eighteen ambulatory patients who had proven metastatic adenocarcinoma of the pancreas and measurable disease but no previous chemotherapy were treated with bisantrene given by constant central intravenous infusion over 72 hours at a total dose of 300 mg/m2 repeated every 3 to 4 weeks. No objective r
## Abstract To determine the maximum tolerated dose of 5βfluorouracil administered as a 120βhour continuous intravenous infusion to pediatric patients, we performed a phase I study using a starting dosage of 900 mg/m^2^/day. The maximum tolerated dosage (MTD) was 1,100 mg/m^2^/day. At this dosage l