A Phase I study of acivicin in refractory pediatric solid tumors
β Scribed by Sylvain Baruchel; Mark Bernstein; V. Michael Whitehead; Susan Devine; Beverly Bell; Ronald Dubowy; Holcombe Grier; Cynthia Kretschmar; Anne-Marie Langevin; Teresa Vietti
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 444 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Fotemustine is a nitrosourea with theoretic and preclinical advantages over the original analogs, carmustine and lomustine, in the treatment of brain tumors. This is the first pediatric Phase I study of fotemustine. ## METHODS Patients younger than 21 with recurrent/res
## Abstract Trimetrexate (TMTX), a lipophilic antifol, was evaluated in a Pediatric Oncology Group (POG) Phase I trial in children with refractory solid tumors. TMTX was administered intravenously daily Γ 5 every three weeks. Starting dose was 6.4 mg/m^2^/day. Dose was escalated by 20% until the ma
## Abstract Eleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5βfluorouracil (5βFU) and cisplatin (DDP). Myelosuppression and vomiting of variable degrees occurred in all. No responses were seen.