## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and docetaxel have single‐agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad
✦ LIBER ✦
A phase I pharmacological and biological study of PI-88 and docetaxel in patients with advanced malignancies
✍ Scribed by Laura Q. M. Chow; Daniel L. Gustafson; Cindy L. O’Bryant; Lia Gore; Michele Basche; Scott N. Holden; Mark C. Morrow; Stacy Grolnic; Brian R. Creese; Kaye L. Roberts; Kat Davis; Russell Addison; S. Gail Eckhardt
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 425 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
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## Abstract ## BACKGROUND A Phase I study using weekly docetaxel and gemcitabine was conducted to investigate toxicity; to determine the maximum tolerated dose (MTD) of each agent; and, in a preliminary fashion, to determine the antitumor activity of the combination. ## METHODS Docetaxel and gem