## Abstract ## Background Almost all concurrent chemoradiation regimens for head and neck are platinum based; however, cisplatin is associated with severe renal, otoβ, and neurotoxicity. Hydroxyurea (HU) has been associated with fewer irreversible toxicities. We obtained HU in parenteral form to b
A phase I clinical trial of prolonged infusion of hydroxyurea in combination with hyperfractionated, accelerated, external radiation therapy in patients with advanced squamous cell cancer of the head and neck
β Scribed by Jonathan J. Beitler; Richard V. Smith; Hilda Haynes; Carl E. Silver; Astrid Quish; Tamar Kotz; Maria Serrano; Allan Brook; Scott Wadler
- Book ID
- 110232130
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 67 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-6997
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π SIMILAR VOLUMES
## Background: Both twice daily fractionated radiotherapy and concurrent cisplatin with once-daily radiotherapy have been shown to improve local disease control in patients with head and neck cancer. the objective of this phase i trial was to determine the maximum tolerated dose of cisplatin which
## Abstract ## BACKGROUND The authors conducted a Phase I/II study in patients with a poor prognosis who had locally advanced squamous cell carcinoma of the head and neck (SCCHN) and who were treated initially with induction chemotherapy. Patients were treated with weekly docetaxel and concurrent