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A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer

✍ Scribed by R. O’Connor; M. O’Leary; J. Ballot; C. D. Collins; P. Kinsella; D. E. Mager; R. D. Arnold; L. O’Driscoll; A. Larkin; S. Kennedy; D. Fennelly; M. Clynes; J. Crown


Publisher
Springer
Year
2006
Tongue
English
Weight
291 KB
Volume
59
Category
Article
ISSN
0344-5704

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Phase I and pharmacokinetic study of a l
✍ Francis J. Giles; Martin S. Tallman; Guillermo Garcia-Manero; Jorge E. Cortes; D 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB

## Abstract ## BACKGROUND OSI‐211 is a low‐clearance, unilamellar liposomal formulation of a water‐soluble camptothecin analogue, lurtotecan. OSI‐211 has significant activity in severe combined immunodeficient mouse models of human leukemia. ## METHODS This study was conducted to define the dose