Pharmacokinetics of BW12C and mitomycin C, given in combination in a phase 1 study in patients with advanced gastrointestinal cancer
β Scribed by Ian F. Dennis; Jonathan R. S. Ramsay; Paul Workman; Norman M. Bleehen
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 560 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0344-5704
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In a Phase I1 study, 50 patients with advanced breast cancer were treated with a combination of 5fluorouracil(lOO0 mg/m2 on days 1 and 2) and mitomycin C (6 mg/m2 on day 2) (FuMi regimen). The courses were repeated every third to sixth week. Although 35 patients had previously received combination c
Twenty-seven patients with assessable, regionally advanced, or metastatic upper aerodigestive cancer of diverse histology received a combination of mitomycin C, adriamycin, and cisdiamminedichloroplatinum. All patients had previously received extensive surgery and/or radiation therapy. We observed a