A Pharmacological Study of N,N-Diethyl-[5-(2,4-Dichlorophenyl)-4-Thiapentyl] Amine Hydrochloride*
β Scribed by Hammond, P.V. ;Edwards, L. D
- Publisher
- Elsevier
- Year
- 1952
- Weight
- 176 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0095-9553
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## Abstract An efficient procedure for the synthesis of __N__βalkylβ2,5βdiarylβ1,3βdioxolβ4βamines **3** __via__ a oneβpot reaction of aromatic aldehydes **2** and alkyl isocyanides **1** at room temperature in good yields is described (__Schemeβ 1, Table__).
The partial ergoline LY228729 (1) which was a potent 5HT 1A agonist has been studied clinically. Somewhat later, a related analog, (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine (2a) which in addition to potent 5HT 1A agonist activity was a muscarinic antagonist, was chosen