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A Pd(0)-Catalyzed Direct Dehydrative Coupling of Terminal Alkynes with Allylic Alcohols To Access 1,4-Enynes

✍ Scribed by Li, Yang-Xiong; Xuan, Qing-Qing; Liu, Li; Wang, Dong; Chen, Yong-Jun; Li, Chao-Jun


Book ID
120938523
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
434 KB
Volume
135
Category
Article
ISSN
0002-7863

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The first direct coupling of 1-trialkyls
✍ Ulla Halbes; Philippe Bertus; Patrick Pale πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 61 KB

1-Trialkylsilyl-1-alkynes can be directly coupled with vinyl triflates in the presence of TBAF, 3H 2 O and a catalytic amount of AgI and Pd(PPh 3 ) 4 . Functionalized enynes can thus be obtained in good to excellent yields without prior deprotection of the alkyne.