✦ LIBER ✦

A partial model of the erythropoietin receptor complex

✍ Scribed by Caravella, Justin A.; Lyne, Paul D.; Richards, W. Graham

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 836 KB
Volume: 24
Category: Article
ISSN: 0887-3585
DOI: 10.1002/(sici)1097-0134(199603)24:3<394::aid-prot13>3.0.co;2-h

No coin nor oath required. For personal study only.

✦ Synopsis

A model of the structure of erythropoietin (Epo) is presented based on structural homology to other hemopoietic cytokines. A model of the erythropoietin receptor complex w a s made based on evidence that this includes a homodimer of the receptor chain with known sequence. Key interactions are noted which explain data from mutation experiments, although at not all residues believed to be important to binding of Epo are at the interface. This is consistent with the hypothesis that the Epo receptor complex includes proteins in addition to the cloned receptor chain that have been cross-linked to Epo (Todokoro et al., Proc.

📜 SIMILAR VOLUMES

Kindling: An animal model of complex par

Kindling: An animal model of complex partial epilepsy

✍ Dr James O. McNamara 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 591 KB

Differential pharmacokinetic analysis of

Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep

✍ Mohammed H. El-Komy; Robert L. Schmidt; John A. Widness; Peter Veng-Pedersen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 1 views

Ambient error weighted partial least-squ

Ambient error weighted partial least-squares regression: a new receptor model

✍ Shizoom Wang; Timothy Larson 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 464 KB

In the proposed model, both the amblent data and the source profiles were weqbted by the amblent mass scaled amblent error The comparison between thts model and the effectwe varrance we&ted chemtcal mass balance-type model was done usmg NBS test data sets The compared results show that the amblent e

Construction of the Simplest Model to Ex

Construction of the Simplest Model to Explain Complex Receptor Activation Kinetics

✍ R.P. BYWATER; A. SØRENSEN; P. RØGEN; P.G. HJORTH 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 178 KB

We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor [corrected] models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer mod

Problem-solving test: Expression cloning

Problem-solving test: Expression cloning of the erythropoietin receptor

✍ József Szeberényi 📂 Article 📅 2008 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 54 KB 👁 2 views

Rational Design of Receptor Partial Agon

Rational Design of Receptor Partial Agonists and Possible Mechanisms of Receptor Partial Activation: A Theory

✍ Bao Ting Zhu 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 397 KB

Partial activation of membrane receptors using specific partial agonists may be particularly beneficial to the treatment of some chronic diseases like congestive heart failure, because receptor partial activation usually avoids overstimulation and also minimizes desensitization. At present, partial