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A Parallel Synthesis Scheme for Generating Libraries of DNA Polymerase Substrates and Inhibitors.

✍ Scribed by Heike Strobel; Laurence Dugue; Philippe Marliere; Sylvie Pochet

Publisher
John Wiley and Sons
Year
2003
Weight
49 KB
Volume
34
Category
Article
ISSN
0931-7597

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A Parallel Synthesis Scheme for Generati
A Parallel Synthesis Scheme for Generating Libraries of DNA Polymerase Substrates and Inhibitors
✍ Heike Strobel; Laurence DuguΓ©; Philippe MarliΓ¨re; Sylvie Pochet πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 438 KB πŸ‘ 1 views

We report a combinatorial approach aimed at producing in a single step a large family of nucleoside triphosphate derivatives that could be tested for their ability to be substrates for DNA polymerases. We propose as a unique triphosphate building block a nucleotide with a hydrazine function anchored