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A one-step synthesis of azeto(3,2-d)isoxazoline

✍ Scribed by Takushi Kurihara; Masanobu Mori


Book ID
108382282
Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
175 KB
Volume
17
Category
Article
ISSN
0040-4039

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## Abstract The proton at 3‐position of oxazepam (7‐chloro‐1,3‐dihydro‐3‐hydroxy‐5‐phenyl‐2__H__‐1,4‐benzodiazepin‐2‐one) undergoes a deuterium exchange in deuterated alkaline methanol. A base‐catalyzed keto‐enol tautomerism is proposed to be responsible for the observed deuterium exchange. This si