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A one-step synthesis of [3-2H]oxazepam

✍ Scribed by Dr. Shen K. Yang; Ziping Bao; Magang Shou

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
414 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The proton at 3‐position of oxazepam (7‐chloro‐1,3‐dihydro‐3‐hydroxy‐5‐phenyl‐2__H__‐1,4‐benzodiazepin‐2‐one) undergoes a deuterium exchange in deuterated alkaline methanol. A base‐catalyzed keto‐enol tautomerism is proposed to be responsible for the observed deuterium exchange. This simple method is a considerable improvement of the multi‐step synthetic procedure reported in the literature.

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