𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A one-step synthesis of 2,6-disubstituted anilines from aliphatic compounds

✍ Scribed by P. Camps; C. Jaime; J. Molas

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
222 KB
Volume
22
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A one-step synthesis of 2,6-disubstituted anilines by reaction of enamines derived from acyclic ketones of the type RCH2COCH2R' and 1,3-dichloro-1,3-dimethoxypropane is described. We have recently described the preparation of 2,4-dialkoxybicyclop.2.1]octan-8-ones1 and 2,4-dimethoxybicyclop.3.1]nonan-g-ones ' by condensation of the appropriate 1,3-dichloro-1,3-dialkoxypropane with N-(cyclopent-1-en-1-yl)pyrrolidine and N-(cyclohex-l-en-1-yl)pyrrolidine, respectively. We describe in this communication a medium yield preparation of 2,6-disubstituted anilines by reaction of enamines3 derived from acyclic ketones of the type RCH2COCH2R' with 1,3-dichloro-1,3-dimethoxypropane! X Cl OMe X H CHp-R' + LH2 R EtN(i-Pr)n

πŸ“œ SIMILAR VOLUMES

A practical one-pot synthesis of 2,3-dis
A practical one-pot synthesis of 2,3-disubstituted indoles from unactivated anilines
✍ Makoto Tokunaga; Mitsuru Ota; Masa-aki Haga; Yasuo Wakatsuki πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 69 KB

2-Substituted-3-methyl indoles are synthesized with good regioselectivity from readily available substrates and catalysts, i.e. the reaction of anilines with propargyl alcohols in the presence of 0.36-1 mol% Ru 3 (CO) 12 .

Aminohaloborane in organic synthesis. VI
Aminohaloborane in organic synthesis. VIII. A one-step synthesis of 2-Aminobenzhydrols from anilines
✍ Tatsuo Toyoda; Kazuyuki Sasakura; Tsutomu Sugasawa πŸ“‚ Article πŸ“… 1980 πŸ› Elsevier Science 🌐 French βš– 202 KB

2-Aminobenshydrols were obtained regiospecifically from anilines and benzaldehydes with the aid of phenyldichloroborane and triethylamine via N-anilinophenylchloroborane. We have recently reported a specifically ortho-directed reaction of secondary aniline8 (la) with mainly aromatic aldehydes to gi

ChemInform Abstract: A Practical One-Pot
ChemInform Abstract: A Practical One-Pot Synthesis of 2,3-Disubstituted Indoles from Unactivated Anilines.
✍ Makoto Tokunaga; Mitsuru Ota; Masa-aki Haga; Yasuo Wakatsuki πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v