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A one step synthesis of 1-alkylpyrazolo[5,4-d]pyrimidines

✍ Scribed by Scott Boyd; Leonie Campbell; Wensheng Liao; Qinghong Meng; Zuozhong Peng; Xiaoping Wang; Michael J. Waring

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 164 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.10.065

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✦ Synopsis

A new synthesis of 1-alkylpyrazolo [5,4-d]pyrimidines is described. The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with various substituted hydrazines provides such compounds in a single step from commercially available starting materials. This method has advantages over methods currently described in the literature for the construction of such ring systems.

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