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One-step synthesis of 2,4,5-trisubstituted pyrimidines

✍ Scribed by Chuang-Jun Zhang; Wen-Yong Han; Mi-Xiang Gao; Fei-Fei Xu; Zun-Ting Zhang

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
157 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A simple and straightforward methodology towards the synthesis of 2,4,5‐trisubstituted pyrimidines has been developed by one‐step reaction of isoflavones with thiourea or guanidine. Ten 2‐mercapto‐4,5‐diphenylpyrimidines and eight 2‐amino‐4,5‐diphenylpyrimidines were reported. All of them were characterized by FT‐IR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2011).

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