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A one-pot three-component reaction to access 1-alkyl-2-aryl-5-nitrobenzimidazoles under solvent-free conditions

✍ Scribed by F. Anthony Romero; Remond Moningka

Book ID: 104098001
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 565 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.06.094

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✦ Synopsis

A novel and expeditious method to access 1-alkyl-2-aryl-5-nitrobenzimidazoles has been developed. Enlisting solvent-free conditions, 2-fluoro-5-nitroaniline, a primary amine, and substituted aldehyde were melted together in one-pot to generate a variety of 1-alkyl-2-aryl-5-nitrobenzimidazoles.

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