A one-pot three-component reaction for the preparation of highly functionalized tryptamines
β Scribed by Se Jeong Yeo; Yongxiang Liu; Xiang Wang
- Book ID
- 113929131
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 296 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0040-4020
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## Abstract magnified image 1,8βDiazabicyclo[5.4.0]undecβ7βene (DBU) efficiently catalyzes threeβcomponent oneβpot condensations of aldehyde, malononitrile, and thiophenol to produce highly functionalized pyridines in excellent yield in aqueous ethanol. J. Heterocyclic Chem., **46**, 69 (2009).
General procedure: A flame-dried round-bottomed flask was charged with 4 (1 equiv) and the olefin cross partner (3.0 equiv). A rubber septum was attached, dichloromethane was added (0.2 Β± 0.3 n in 4), and argon was bubbled through the resultant solution for 10 min. Under a stream of argon, 3 (0.050