A one-pot synthesis of 8-amino-1-methoxy-6H-dibenzo[b,d]pyran-6-one

✍ Scribed by J. A. Jilani

• Book ID: 111491081
• Publisher: Versita
• Year: 2007
• Tongue: English
• Weight: 123 KB
• Volume: 61
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-007-0056-x

✦ Synopsis

Abstract

8-Amino-1-methoxy-6H-dibenzo[b,d]pyran-6-one was synthesized in a one-pot reaction of 2′,6′-dimethoxy-4-nitro-1,1′-biphenyl-2-carboxylic acid methyl ester using hydroiodic acid as a reagent to effect O-demethylation, lactonization, and nitro reduction to amine. This new reaction represents an improved alternative to the previously reported three-step reactions for this transformation.