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A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels

✍ Scribed by Alan A. Wilson; Dimitri E. Grigoriadis; Robert F. Dannals; Hayden T. Ravert; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
290 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64%) of pure, high specific activity (350 -1500 mCi/pmol) 1251 labelled iodoatyl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

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