✍ Scribed by Lianyou Zheng; Jinbao Xiang; Xu Bai
No coin nor oath required. For personal study only.
A simple one-pot procedure for ring enlargement of -chloromethyl N-containing heterocycles has been developed. By reaction of chloromethyl tetrahydroisoquinoline and its thieno analog with benzyl or allyl bromide under basic conditions, ring expansion and N-substitution were achieved simultaneously. The key to the transformation was proposed to involve the formation of aziridinium salt and subsequent bond breaking between the nitrogen and tertiary carbon atoms.
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## Abstract A variety of novel N‐t‐butyl‐N′‐aminocarbonyl‐N‐(substituted)benzoylhydrazines containing α‐aminoalkylphosphonate groups were synthesized. Treatment of α‐aminoalkylphosphonates with triphosgene yielded α‐isocyanatoalkylphosphonates, and subsequent addition with N‐t‐butyl‐N‐substituted b