A simple one-pot procedure for ring enlargement of -chloromethyl N-containing heterocycles has been developed. By reaction of chloromethyl tetrahydroisoquinoline and its thieno analog with benzyl or allyl bromide under basic conditions, ring expansion and N-substitution were achieved simultaneously.
A One-Pot Procedure for Ring Enlargement of α-Chloromethyl N-Containing Heterocycles.
✍ Scribed by Lianyou Zheng; Jinbao Xiang; Xu Bai
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 22 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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