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A numerical method for biphasic curve fitting with a programmable calculator

✍ Scribed by Dušan Ristanović; Dejan Ristanović; Jovo Malešević; Branko Milutinović

Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
1006 KB
Volume
12
Category
Article
ISSN
0010-4825

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✦ Synopsis

Elimination kinetics ofbromsulphalein (BSP) after a single injection into the circulation of rats were examined by means of a four-compartment model. BSP plasma concentrations were measured calorimetrically. A program written for the Texas Instruments TI-59 programmable calculator is presented, which will calculate the fractional blood clearance of BSP using an iteration procedure. A simple method of fitting biphasic decay curves to experimental data is also proposed. Decay curve fitting Bromsulphalein (BSP) Rats Compartmental analysis Plasma kinetics Fractional blood clearance Programmable calculator (D-59) Iteration procedure Fast mode

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