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A novelMSH2mutation in a Chinese family with hereditary non-polyposis colorectal cancer

✍ Scribed by Duo Zheng; Tiegang Li; Xiaoping Liu; Weixin Hu; Hanchun Chen; Yongjia Yang


Book ID
106059318
Publisher
Springer
Year
2007
Tongue
English
Weight
258 KB
Volume
22
Category
Article
ISSN
0179-1958

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Hereditary non-polyposis colorectal cancer (HNPCC), the most common hereditary colon cancer syndrome, is a dominant disorder caused by germline defects in mismatch repair (MMR) genes. Identification of MMR gene mutations can have direct clinical implications in counseling and management of HNPCC fam