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A novel type of EWS–CHOP fusion gene in myxoid liposarcoma

✍ Scribed by Yoshito Matsui; Takafumi Ueda; Takahiro Kubo; Tadashi Hasegawa; Yasuhiko Tomita; Mina Okamoto; Akira Myoui; Shigeki Kakunaga; Natsuo Yasui; Hideki Yoshikawa


Book ID
116293353
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
550 KB
Volume
348
Category
Article
ISSN
0006-291X

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✍ Sofia Thelin-Järnum; Carin Lassen; Ioannis Panagopoulos; Nils Mandahl; Pierre Åm 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 550 KB

Myxoid liposarcomas (MLS) carry a t(12;16) or, more rarely, a t(12;22) resulting in fusion of the transcription factor gene CHOP on chromosome 12 with TLS/FUS on chromosome 16 or EWS on chromosome 22. The chimeric TLS-CHOP or EWS-CHOP proteins most probably function as abnormal transcription factors