✦ LIBER ✦

A novel total synthesis of (+)-himbacine, a potent antagonist of the muscarinic receptor of M2 subtype

✍ Scribed by Masanori Takadoi; Tadashi Katoh; Akihiro Ishiwata; Shiro Terashima

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 241 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00473-6

No coin nor oath required. For personal study only.

✦ Synopsis

The title total synthesis was achieved by a method featuring highly stereoselective intermolecular Diels-Alder reaction of the tetrahydroisobenzofuran 5 with the chiral butenolide 6 as the key step. The cycloadduct 4 was converted to the title alkaloid by way of the known sulfone 2 in 17 steps.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Novel Total Synth

ChemInform Abstract: A Novel Total Synthesis of (+)-Himbacine, a Potent Antagonist of the Muscarinic Receptor of M2 Subtype.

✍ Masanori Takadoi; Tadashi Katoh; Akihiro Ishiwata; Shiro Terashima 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

Synthetic Studies of Himbacine, a Potent

Synthetic Studies of Himbacine, a Potent Antagonist of the Muscarinic M2 Subtype Receptor. Part 1. Stereoselective Total Synthesis and Antagonistic Activity of Enantiomeric Pairs of Himbacine and (2′S,6′R)-Diepihimbacine, 4-Epihimbacine, and Novel Himbacine Congeners.

✍ Masanori Takadoi; Tadashi Katoh; Akihiro Ishiwata; Shiro Terashima 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 118 KB 👁 1 views

Synthesis and Muscarinic M2 Subtype Anta

Synthesis and Muscarinic M2 Subtype Antagonistic Activity of Unnatural ent-Himbacine and an Enantiomeric Pair of (2′S,6′R)-Diepihimbacine.

✍ Masanori Takadoi; Shiro Terashima 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 102 KB 👁 2 views

A Formal Synthesis of a Muscarinic M1 Re

A Formal Synthesis of a Muscarinic M1 Receptor Antagonist, (-)-TAN1251A.

✍ Hirotake Mizutani; Jun Takayama; Yukio Soeda; Toshio Honda 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 57 KB 👁 1 views

Catalytic Asymmetric Total Synthesis of

Catalytic Asymmetric Total Synthesis of the Muscarinic Receptor Antagonist (R)-Tolterodine

✍ Christian Hedberg; Pher G. Andersson 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 2 views

The synthesis of potent thromboxane A2/

The synthesis of potent thromboxane A2/ prostaglandin endoperoxide receptor antagonist

✍ Nobuyuki Hamanaka; Takuya Seko; Tohru Miyazaki; Masao Naka; Kyoji Furuta; Hisash 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 237 KB

In diseases such as angina pectoris and thrombosis, thromboxane Az(TXA2)