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A novel three-component reaction of a secondary amine and a 2-hydroxybenzaldehyde derivative with an isocyanide in the presence of silica gel: an efficient one-pot synthesis of benzo[b]furan derivatives

✍ Scribed by Ali Ramazani; Amir Tofangchi Mahyari; Morteza Rouhani; Aram Rezaei

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 183 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.07.115

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✦ Synopsis

Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between an electronpoor 2-hydroxybenzaldehyde derivative and a secondary amine in the presence of silica gel proceeds smoothly at room temperature to afford benzo[b]furan derivatives in high yields.

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